Hi all -

Don't know if anyone's still reading after my mention of PBPK model, but just in case!- I have just started a Phd in PBPK modelling (physiologically based pharmacokinetic) - in France! (I'm english...) and since it is not lab-based at all I will need to find data to build, develop, test the model... in your experience, what is the best way to get this data? Can you just email the authors of publications and ask them for their raw concentration data, or are there any useful websites with data for marketed drugs etc?

Specifically, it's a PBPK model for the brain, so I also need concentrations in brain or brain microvessels etc, which will be slightly more difficult to find, I fear...

don't actually know what the best way would be... authors might be reluctant to give you raw data, since pharmaco-therapeutic research is usually classified because of patents and industry money... perhaps try with researchers from your own institution first?