Signup date: 14 Jan 2013 at 9:20am
Last login: 21 Mar 2018 at 10:49am
Post count: 125
Title : Behavior of streptozotocin-diabetic mice in tests of exploration, locomotion, anxiety, depression and aggression.
Authors : Hilakivi-Clarke LA, Wozniak KM, Durcan MJ, Linnoila M.
Journal : Physiology & Behaviour
Publication Date : 1990
Citation : Hilakivi-clarke LA, Wozniak KM, Durcan MJ, Linnoila M. Behavior of streptozotocin-diabetic mice in tests of exploration, locomotion, anxiety, depression and aggression. Physiol Behav. 1990;48(3):429-33.
Direct Link : "http://www.sciencedirect.com/science/article/pii/0031938490903396"
Abstract :
The present study examined behavior of streptozotocin-diabetic mice in Porsolt's swim test, a putative animal model of depression, in the holeboard test of exploration and locomotor activity, in the plus maze test of anxiety, and in the resident-intruder paradigm of aggression. Two weeks after an IP injection of 200 mg/kg streptozotocin, which caused a 20% weight loss and increased fluid consumption and urination, male NIH Swiss mice were found to show lengthened duration of immobility in the swim test. One week of insulin treatment (0.1 IU/g/day) partially antagonized this change. The locomotor activity scores in the streptozotocin-treated mice were lower in the holeboard but higher in the plus maze than in the controls; therefore, the lengthened immobility was not likely to be due to a general motor impairment. No significant changes in the time spent in social interaction or aggressive behavior were found in the streptozotocin-treated mice. The results indicate that streptozotocin-treated mice show lengthened immobility in the swim test.
Wish I could reach the second one but at least, first one is below :
For article that titled "High power electrochemical capacitors based on carbon nanotube electrodes", follow the link below :
http://www.sendspace.com/file/ezhok9
Title : Effects of neuroleptic drugs, clonidine and lithium on the expression of conditioned behavioral excitation in rats.
Authors : Poncelet, M., Dangoumau, L., Soubrié, P. & Simon, P.
Journal : Psychopharmacology
Publication Date : 1987
Citation : Poncelet M, Dangoumau L, Soubrié P, Simon P. Effects of neuroleptic drugs, clonidine and lithium on the expression of conditioned behavioral excitation in rats. Psychopharmacology (Berl). 1987;92(3):393-7.
Direct Link : "http://journals.ohiolink.edu/ejc/article.cgi?issn=00333158&issue=v92i0003&article=393_eondcaocbeir"
Abstract :
Rats with a history of daily (21 days) amphetamine (2.5 mg/kg) treatment showed enhanced activity when under placebo in their amphetamine-associated environment. We found that this conditioned effect was reduced by haloperidol (0.06; 0.125; 0.25 mg/kg), pimozide (0.25; 0.5 mg/kg) and sulpiride (8; 16; 32 mg/kg) but only at doses similar to or, in the case of pimozide, higher than those required to antagonize the unconditioned stimulant effects of amphetamine (2.5 mg/kg). Conversely, we observed that clonidine (7; 15; 30; 60 micrograms/kg) or lithium regimen (between days 15 and 21) leading to lithium plasma levels of 1.3 +/- 0.1 mEq/l, abolished amphetamine-conditioned hyperactivity but did not affect the unconditioned stimulation of amphetamine or locomotor activity in control rats. Moreover, we found that hyperactivity induced by the daily anticipation of food delivery shared identical pharmacological sensitivity with the behavioural excitation produced by a conditioning history with amphetamine. In light of the antimanic properties of lithium and clonidine and the ability of this latter drug to reduce noradrenergic transmission, our findings raise the possibility that incentive activity may model noradrenergic-dependent aspects of mania.
Title : Effects of lithium on an amphetamine animal model of bipolar disorder.
Authors : Cappeliez, P. & Moore, E.
Journal : Progress in Neuro-psychopharmacology & Biological Psychiatry
Publication Date : 1990
Citation : Cappeliez P, Moore E. Effects of lithium on an amphetamine animal model of bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry. 1990;14(3):347-58.
Direct Link : "http://journals.ohiolink.edu/ejc/article.cgi?issn=02785846&issue=v14i0003&article=347_eoloaaamobd"
Abstract :
1. This study examines the effects of chronic lithium administration on changes induced by amphetamine administration and withdrawal on open field locomotor activity of rats, and considered as an animal model of behaviors displayed in bipolar disorders. 2. For 21 days, rats were administered either single daily intraperitoneal injections (IP) of 0.9% saline, 0.15 mEq/kg, or 1.5 mEq/kg lithium chloride (LiCl). From day 7 to day 16, half of the animals in each group consisting of 12 rats were administered twice daily IP injections of either 1.5 mg/kg d-amphetamine or 0.9% saline. From day 17 to 21, d-amphetamine was withdrawn. 3. Neither dose of LiCl significantly altered the increases in activity levels produced by amphetamine. The withdrawal of amphetamine lead to an immediate return to baseline activity levels which neither dose of LiCl significantly affected. 4. The absence of interactive effects suggests that the influence of lithium and amphetamine on activity are mediated by different neurotransmitter systems
Title : Rodent Models of Depression: Learned Helplessness Induced in Mice
Authors : Hymie Anisman & Zul Merali
Journal : Current Protocols in Neuroscience
Publication Date : 2001
Citation : Anisman H,Merali Z. (2001). Rodent Models of Depression: Learned Helplessness Induced in Mice. Curr Protoc Neurosci. Published Online.
Direct Link : "http://onlinelibrary.wiley.com/doi/10.1002/0471142301.ns0810cs14/abstract"
Abstract :
Uncontrollable stressors induce a variety of behavioral disturbances that are in many ways reminiscent of the symptoms that characterize clinical depression. These deficits are evident across a range of species, including mice. Given the increasing focus on genetic techniques involving mice to identify the mechanisms subserving these behavioral disturbances (e.g., recombinant, knockout, and transgenic strains), it is of particular interest to provide a detailed description of the method to induce behavioral deficits in response to uncontrollable stressors. This unit describes the procedure used to assess the effects of controllable and uncontrollable shock on subsequent shock escape performance in mice using an escape-delay procedure.
Here it is :
http://www.sendspace.com/file/0q8l07
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