Signup date: 14 Jan 2013 at 9:20am
Last login: 21 Mar 2018 at 10:49am
Post count: 125
Title : In vivo reprogramming of circuit connectivity in postmitotic neocortical neurons.
Authors : De la Rossa A, Bellone C, Golding B, Vitali I, Moss J, Toni N, Lüscher C, Jabaudon D.
Journal : Nature Neuroscience
Publication Date : 2013
Citation : De la rossa A, Bellone C, Golding B, et al. In vivo reprogramming of circuit connectivity in postmitotic neocortical neurons. Nat Neurosci. 2013;16(2):193-200.
Direct Link : "www.nature.com/neuro/journal/v16/n2/full/nn.3299.html"
Abstract :
The molecular mechanisms that control how progenitors generate distinct subtypes of neurons, and how undifferentiated neurons acquire their specific identity during corticogenesis, are increasingly understood. However, whether postmitotic neurons can change their identity at late stages of differentiation remains unknown. To study this question, we developed an electrochemical in vivo gene delivery method to rapidly manipulate gene expression specifically in postmitotic neurons. Using this approach, we found that the molecular identity, morphology, physiology and functional input-output connectivity of layer 4 mouse spiny neurons could be specifically reprogrammed during the first postnatal week by ectopic expression of the layer 5B output neuron–specific transcription factor Fezf2. These findings reveal a high degree of plasticity in the identity of postmitotic neocortical neurons and provide a proof of principle for postnatal re-engineering of specific neural microcircuits in vivo.
Too late for project, unfortunately. I'm praying for if they won't notice the gap on ethical committee...
If it's possible to you to send article, I still wish to read.
Uploading to a filehosting/filesharing web site is an alternative to sending via mail. Yousendit(dot)com is preferable, if you think
Neuroendocrine Profile in a Rat Model of Psychosocial Stress: Relation to Oxidative Stress
Title : Neuromodulation of neuronal circuits: back to the future.
Authors : Marder, E.
Journal : Neuron
Publication Date : 2012
Citation : Marder E. Neuromodulation of neuronal circuits: back to the future. Neuron. 2012;76(1):1-11.
Direct Link : "http://www.sciencedirect.com/science/article/pii/S0896627312008173"
Abstract :
All nervous systems are subject to neuromodulation. Neuromodulators can be delivered as local hormones, as cotransmitters in projection neurons, and through the general circulation. Because neuromodulators can transform the intrinsic firing properties of circuit neurons and alter effective synaptic strength, neuromodulatory substances reconfigure neuronal circuits, often massively altering their output. Thus, the anatomical connectome provides a minimal structure and the neuromodulatory environment constructs and specifies the functional circuits that give rise to behavior.
Created a .pdf with whole full-text articles of your requested journal's issue :
Üç makale de linkteki .rar dosyasında (All three articles are in linked .rar file) :
If you consult your supervisor and use his/her feed-backs in your works, in my opinion, this means he/she has labor. It's very usual all around the world to share work with supervisor. Also if you plan to study with him/her post-doc, you should take account of good relations with a senior colleague.
Effects of cadmium on cardiac metallothionein induction and ischemia–reperfusion injury in rats
http://www.nrcresearchpress.com/doi/abs/10.1139/Y09-046#.USIElx0XEud
Title : Antidepressant Activity of Quercetin, a Bioflavonoid, in Streptozotocin-Induced Diabetic Mice
Authors : Muragundla Anjaneyulu, Kanwaljit Chopra, and Indupal Kaur
Journal : Journal of Medicinal Food
Publication Date : 2004
Citation : Anjaneyulu M, Chopra K, Kaur I. Antidepressant activity of quercetin, a bioflavonoid, in streptozotocin-induced diabetic mice. J Med Food. 2003;6(4):391-5.
Direct Link : "http://online.liebertpub.com/doi/abs/10.1089/109662003772519976"
Abstract :
Depression is highly prevalent in diabetics and is associated with poor glucose regulation and increased risk of diabetic complications. Identification and effective treatment of comorbid depression are increasingly being considered essential components of clinical care of diabetics. In the present study, the antidepressant activity of quercetin (50 and 100 mg/kg, i.p.), a bioflavonoid, was evaluated using the Porsolt forced swimming-induced behavioral despair test in control and 6-week-streptozotocin-induced diabetic mice. The effect of quercetin was compared with that of the classical antidepressants fluoxetine (5 mg/kg, i.p.) and imipramine (15 mg/kg, i.p.). Streptozotocin-induced diabetic mice exhibited prolonged immobility duration during the test as compared with age-matched control mice. Quercetin dose-dependently reduced the immobility period in diabetic mice, and this effect was comparable to that of fluoxetine (5 mg/kg, i.p.) and imipramine (15 mg/kg, i.p.). Fluoxetine and imipramine significantly lowered the immobility time in naive mice also, but quercetin failed to induce any antidepressant activity in naive mice. The results of our preliminary study indicate that quercetin has the potential to be employed as a therapy for depression associated with diabetes.
PostgraduateForum Is a trading name of FindAUniversity Ltd
FindAUniversity Ltd, 77 Sidney St, Sheffield, S1 4RG, UK. Tel +44 (0) 114 268 4940 Fax: +44 (0) 114 268 5766
An active and supportive community.
Support and advice from your peers.
Your postgraduate questions answered.
Use your experience to help others.
Enter your email address below to get started with your forum account
Enter your username below to login to your account
An email has been sent to your email account along with instructions on how to reset your password. If you do not recieve your email, or have any futher problems accessing your account, then please contact our customer support.
or continue as guest
To ensure all features on our website work properly, your computer, tablet or mobile needs to accept cookies. Our cookies don’t store your personal information, but provide us with anonymous information about use of the website and help us recognise you so we can offer you services more relevant to you. For more information please read our privacy policy
Agree Agree