Thank you for the sympathies everyone. It's nice to hear that feeling stupid is normal :D!

having had left industry to start a PhD which is half an half wet lab and bioinformatics, I can say to you that EVERYBODY in the Pharma world is looking for a PhD grad with computational bio background.

So I just read an article online on how to thrive in your PhD (http://neurochambers.blogspot.co.uk/2012/05/tough-love-insensitive-guide-to.html)
One of the suggestions was to start a blog.. and I thought where would be better than here since I will have some audience to give me advice..
I am only 2-weeks in and I am already feeling like I know nothing about anything...
I came from quite a poor academic background, but somehow managed to get into one of UK's top uni's to do my PhD, with only a BSc degree. I guess the passion and my lab experience won my supervisor over? I don't know, all I know is that I feel I don't even know half of the basics yet and there is SO MUCH I need to cover. Yesterday I asked a very stupid question from my supervisor which thinking about it now, questions my whole understanding of my project - I know the answer now and the more I read the Nature reviews, the more I realise I know nothing!
Should I just start off from the basics i.e. different types of genetic mutations (I'm a genetics/neuroscience student) and work my way up?
Obvious answer is yes I guess.
I'm not really sure what I am asking in this thread really...
I guess I am having confidence issues.. I WANT to thrive and succeed in this PhD and get a Nature paper out by the end of the 3 years because I think this is great research and so important, but right now - I feel very very stupid.