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Finding a position after PhD

I have just submitted my thesis last month for review and I am actively applying for postdocs. My PhD research was on biomass conversion to chemicals. I have e mailed to 15-20 profs (different cv and resume to each of them according to their research area) and also applied to some open positions but I haven't received any positive response from them. My PhD mentor says I need to apply to 100-150 people. Is this true?