Signup date: 04 Jul 2008 at 4:04pm
Last login: 25 Apr 2010 at 6:25pm
Post count: 20
The concentration of the cognate protein in the cell is governed by both protein synthesis (driven by transcription) and protein degrdation (influenced by many factors). The expressed gene gives the potential for a protein to be expressed but can't be directly correlated in many cases. See: "Chen, G, Gharib, T G, Huang, C C, et al. Discordant protein and mRNA expression in lung adenocarcinomas, Mol Cell Proteomics, 1, 304-313 (2002)"; "4. Mehra, A, Lee KH, and Hatzimanikatis V. Insights into the relation between mRNA and protein expression patterns: I. Theoretical considerations. Biotechnol Bioeng, 2003. 84 (7) 822-33."; "7. Anderson, L and Seilhamer, J. A comparison of selected mRNA and protein abundances in human liver, Electrophoresis, 18 (3-4), 533-7 (1997)." ; "Doherty MK and Beynon RJ. (2006): Protein dynamics on the scale of the proteome, Exp. Rev. Proteomics, 3 (1), 97-110."
The holidays are in place to ensure that shop workers (often the lowest paid) do have some holiday entitlement. Retail is a thankless task (as someone who worked for 6 years in a shop to fund their undergrad/masters)! It's not too difficult to plan your shopping in advance.... Even "up north" we have 24h supermarkets who all signpost their holiday hours. However, this isn't just a UK phenomenom. I've worked in the US, and trying to get ANYTHING in New York on Thanksgiving (after the parade) is impossible. And you can't buy wine in a supermarket.... or mixers like tonic or coke in a bottle shop. Now that's weird!
Or you are a poor student! A supervisor can only take you so far. It's your PhD to defend/discuss and the viva is the perfect time to take responsibility for your research and your work. The viva is there to ensure that you have performed the work outlined in the thesis and understand both the theoretical background and the wider context of your work. It is also there to discuss any deficiencies and correct any errors. You can fail, or alternatively, be directed to substantially enhance your work. Most people do ok though.
CONTD... of supervisors is not reported on this forum.... They are not all out to get you. But remember, a PhD is not a right. It is something that must be earned. Not just through hard work, but by intellectual vigour, stamina and the ability to defend your work in the context of the wider field. You are lucky to have this opportunity. It is up to you to maximise it!
to reply to the comment that supervisors don't feel as much for your PhD as you do. Yes, I concur, however (especially in the sciences) they have a lot riding on your success rate - their progression is linked to this - and, contrary to many posters belief's, a lot of supervisors do care about their pastoral duties and are affected by your life problems - it does impact on them as well!! A happy student is a good student. Unfortunately, the good experiences and good parctice of the MAJORITY
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